the endocannibinoid System Process

Endocannabinoids

Endocannabinoids, also known as endogenous cannabinoids, are molecules that are naturally created in the body. These molecules interact with the ECS by carrying signals to different parts of the body. The two known endocannabinoids the body creates are anandamide and 2-arachidonoylglycerol (2-AG). These endocannabinoids are made from fat-like molecules at the exact moment they are needed and are immediately used. This means the body does not need to store endocannabinoids for later use. The production of endocannabinoids may be affected by a person’s diet, exercise, and sleep.
 

Cannabinoid Receptors

The cannabinoid receptors in the ECS are how the endocannabinoids send signals to the cell in different parts of the body. The endocannabinoids bind with the receptors which then transmit information to the cells in a specific area to signal a cellular response. The response varies depending on the kind of endocannabinoid and where the receptors are located.

 

The only two receptors scientists have yet discovered are called CB1 and CB2 receptors. These two receptors are found in different parts of the body. CB1 receptors are mostly found in the central nervous system, while CB2 receptors are typically found in the peripheral nervous system. The different receptors are activated when regulation is required and is triggered by the endocannabinoids.

 

Enzymes

The enzymes in the ECS break down the endocannabinoids after the function is carried out. The main enzymes that are involved in this process are fatty acid amide hydrolases (FAAH) and monoacylglycerol acid lipases (MAG lipase). These enzymes break down different kinds of endocannabinoids after it has completed its process. FAAH enzymes break down anandamides and MAG lipase enzymes break down 2-AGs. The enzymes make this process unique to other molecular signals in the body because the enzymes ensure the endocannabinoids are used and are broken down once no longer needed. 

 

Activating the endocannibinoid system
 

Sometimes the body doesn’t naturally produce enough endocannabinoids for the endocannabinoid system to work properly. There are ways the ECS system can be stimulated to improve function and increase endocannabinoid production. Endocannabinoids that aren’t produced in the body and are found outside of the body are called cannabinoids, or phytocannabinoids for those found in plants. These cannabinoids are found in plants, foods, and herbs and can help stimulate the ECS. 

 

There are some foods and spices that contain natural cannabinoids that can act as an endocannabinoid when consumed. Cannabinoids were previously believed to only exist in the human body and in cannabis plants, but we now know that is not the case. Some vegetables contain cannabinoids, like broccoli, brussels sprouts, cauliflower, and kale. Cinnamon, pepper, cloves, and oregano also contain cannabinoids. There are also foods that can help increase endocannabinoid production in the body. These include foods containing essential fatty acids, like chia seeds, eggs, flax seeds, and walnuts. Chocolate and herbs can also help increase endocannabinoid production. Adding these foods to your diet may help increase endocannabinoid production and improve ECS function.

 

Hemp and cannabis plants contain over 100 natural cannabinoids. The main cannabinoids these plants are known for are tetrahydrocannabinol (THC) and cannabidiol (CBD). Hemp products can be taken in various forms in order to stimulate the endocannabinoid system.
 

what is the effect of cannabinoids on CB1 Receptor

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CB1 is activated by a class of chemical compounds known as cannabinoids. Cannabinoids are generally classified based on how they're produced. Endocannabinoids are produced naturally inside your own body. Phytocannabinoids are produced in plants, most notably cannabis. Labs can also synthetically produce usable cannabinoids that function similar to a naturally-produced cannabinoid.

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The reason that cannabis has such noticeable impacts on your body is because the cannabinoids it produces activate the CB1 and CB2 receptors. When you consume cannabis, the cannabinoids from the plant interact with the cannabinoid receptors in your body, thereby triggering whatever function these receptors play.

Feeling High 

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Among many other things, an important CB1 receptor function is to help regulate and control the brain's limbic and reward circuitry. The CB1 receptor influences dopamine transmission and produces a euphoric high when triggered by THC.

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Pain Relief

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In addition to facilitating the euphoric effects of cannabis, CB1 is also involved in the brain's top-down control of pain. CB1's main point of pain mitigation is in the midbrain, where the pain “headquarters” is located. Both cannabinoids and opioids alleviate pain through this descending pathway. This is the reason THC is a more effective pain reliever than CBD. In order to have a profound alleviating effect on pain, many patients may need to recruit CB1 receptors in the brain. CBD doesn't activate CB1 receptors, and is, therefore, less effective in some people to alleviate pain compared with THC. However, CBD is an effective anti-inflammatory, so for some people it is effective on its own. 

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Sedation and Motor Control
 

Sedation and impairment of motor skills brought on by endocannabinoid signaling are likely mediated by CB1 receptors in the basal ganglia, where the brain coordinates movement.

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Cognition and Memory Impairment

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Cannabis' ability to affect cognition and impair memory occurs through the activation of CB1 receptors in the hippocampus.

 

Tachycardia

Cannabis is known for its ability to produce an abnormally fast heart rate, also known as tachycardia. CB1 receptors located on cardiac cells may play a role in tachycardia when directly activated. CB1 receptors are prominent in areas of the autonomic nervous system, including the medulla, which is responsible for involuntary life functions like breathing and heart rate. CB1 receptors are abundant in the medulla oblongata, where the tip of the spinal cord connects with the brain and where the body's involuntary vital functions are controlled. 

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Appetite
 

As part of the endocannabinoid system, CB1 receptors, especially in the hypothalamus, play a big role in appetite and metabolism. CB1 has a role in both the “energetic,” or survival-based drive to eat, and the “hedonic” drive, or the drive to eat for pleasure. Newly discovered interactions between the ECS and the gut microbiome, or “community” of microorganisms within the gut, may also play a role in the body's metabolic functions.

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does thc bind to cb1 receptors?
 

According to an article published in the British Journal of Pharmacology, THC is a CB1 and CB2 agonist. That means that THC binds to cannabinoid receptors in your body and mimics the function and role of endocannabinoids. Essentially, a THC molecule produces its effects by activating the CB1 receptor or CB2 receptor to which it binds.

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does cbd bind to cb1 receptors?
 

Within your body's endocannabinoid system, there are no specific CBD receptors. Rather, cannabinoids bind to CB1 and CB2 receptors, where they act as either agonists—mimicking endocannabinoids produced by your body—or antagonists—blocking receptors and limiting their activity. THC is an agonist and CBD is an antagonist. It blocks cannabinoid receptors rather than activating them, which is why CBD is thought to counteract some of the effects produced by THC.

 

Summary
 

The endocannabinoid system is a biological signaling system in the body that uses endocannabinoids, receptors, and enzymes to create a state of homeostasis. We at Texas Bud-eez believe in this system as it has proven to be effective amongst us. We want to be able to help our customers using a more natural remedy in improving the processes that ECS is meant to boost. We want to provide you with as many facts as possible so you, our customers, know we are creating the safest product on the market for your use.  While there are many foods that do produce the natural cannabinoids that your system needs, using our products will produce enough cannabinoids in your body. It gives a natural effect that you can recognize quicker than introducing foods into your diet that may take time to show a change. Because CBD and the Delta-8 receptors will bind more quickly the effect will be more noticeable, we believe. However, each person will have a different reaction and we cannot wait to hear about your success.